AUTHOR=Ardeleanu Valeriu , Jecan Radu Cristian , Moroianu Marius , Teodoreanu Razvan Nicolae , Tebeica Tiberiu , Moroianu Lavinia Alexandra , Bujoreanu Florin Ciprian , Nwabudike Lawrence Chukwudi , Tatu Alin Laurentiu 

TITLE=Case report: Abrikossoff's tumor of the facial skin

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1149735

DOI=10.3389/fmed.2023.1149735

ISSN=2296-858X

ABSTRACT=Abrikossoff tumors are also known as granular cell tumors (GCT), originating from Schwann cells. The most common location is in the oral cavity, followed by the skin, but they can also be found in the breast, digestive tract, tracheobronchial tree or central nervous system.  They can affect both sexes at any age, with a higher incidence between 30-50 years and a slight predisposition for females. They are usually solitary tumors but may also be multifocal. Most of the time they are benign, the malignancy being exceptional in less than 2% of cases. Clinically, they appear as solid, well-defined, painless tumors, located subcutaneously with dimensions that can reach up to 10 cm. The definitive diagnosis is based on the immunohistochemical examination and the treatment for benign tumors consists of  surgical excision. Chemotherapy or radiotherapy may be required for malignant lesions, but the treatment regimens and their benefits remain unclear. This paper presents the case of a 12-year-old girl with a benign GCT, located in the skin on the mandibular line.