In this Research Topic, clinicians will find “food for thoughts” on the diagnosis and treatment of corneal pathologies throughout interesting original articles as well as case reports and reviews of the international literature.
In the article by Jan et al., the authors will focus on patients with Atopic keratoconjunctivitis (AKC), which often present itself in association with several anterior segment and eyelid diseases. The risk of recurrent corneal erosion, a relative common corneal condition, in patients with AKC will be analyzed in this study.
Corneal neovascularization, a sight-threatening condition, and the second cause of blindness worldwide, can be provoked by several ocular diseases, mostly associated with acute or persistent inflammation. The article by Lasagni Vitar et al. will try to measure the impact of corneal neovascularization on visual acuity and corneal sensitivity, providing an evaluation of its prevalence in patients affected by ocular surface diseases.
Keratoconus, an ectatic disorder with highly complex and varied causes, characterized by progressive steepening of paracentral cornea, with irregular astigmatism and visual function worsening, is the main topic of three articles of this Research Topic.
In particular, the study by Nicula et al. will focus on patients with abnormal findings in topography and tomography maps but with subclinical or clinical Keratoconus, in order to assess the efficacy of topographical and tomographical indices given by the Scheimpflug tomography.
The case report by Nuzzi et al. will discuss the management of a young keratoconus patient, initially treated with corneal cross-linking and subsequently implanted with intracorneal rings segment for visual rehabilitation. The patient, complaining visual acuity reduction and ocular discomfort, during slit lamp examination, presented superior ring extrusion, corneal thinning, and micro-perforation into the anterior chamber.
In the article by Ahn et al., authors will discuss the application of artificial intelligence for keratoconus screening, based on the results of basic ophthalmologic examinations.
Trichilemmal carcinoma (TLC) is a rare malignant adnexal tumor that usually develops as a large, solitary, multilobular lesion, providing a typical histopathology keratinization, and a peripheral palisading pattern. The article by Zhang et al. will show a case of corneal perforation caused by eyelid margin trichilemmal carcinoma.
Currently, corneal refractive surgery (CRS) is widely used to correct refractive errors. It is well-known that this procedure induces changes in the corneal structure and its biomechanics (1) which will make intraocular pressure (2), corneal power measurements (3), as well as intraocular lens power calculation (4) challenging. However, if CRS can induce anterior chamber depth and axial length changes (5, 6), is a still debated Research Topic, that will be discussed in the review “Unexpected ocular morphological changes after corneal refractive surgery.”
The review article by Ramachandran et al. will discuss the role of autophagy, a mechanism whereby cells respond to stress, and mitophagy, a selective form of autophagy, acting in clearing damaged mitochondria. Impairment or inhibition of these processes have been linked to corneal diseases, degenerations, and dystrophies. The review will summarize the current body of knowledge on these corneal processes, helping to better understand the mitochondrial dysfunction.
Overall, the eight articles in this Research Topic: The cornea is not a piece of plastic: lesson from the last 10 years, will provide a broad discussion of recent insights into corneal diseases that covers consolidated knowledge and interesting developments described in clinical studies as well as in basic science.
In the last 10 years the cornea has been incised, excised, heated, implanted, flapped, zapped, and cross linked, in the future can be plasticized also (7).
We believe the collections are informative for basic researchers, clinical scientists, and patients.
Statements
Author contributions
LC, MD, and MB contributed to conception, design of the study, and wrote the manuscript. All authors contributed to manuscript revision, read, and approved the submitted version.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
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Rosa N Lanza M De Bernardo M Signoriello G Chiodini P . Relationship between corneal hysteresis and corneal resistance factor with other ocular parameters. Semin Ophthalmol. (2015) 30:335–9. 10.3109/08820538.2013.874479
2.
De Bernardo M Capasso L Caliendo L Vosa Y Rosa N . Intraocular pressure evaluation after myopic refractive surgery: A comparison of methods in 121 eyes. Semin Ophthalmol. (2016) 31:233–42. 10.3109/08820538.2014.962156
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Rosa N De Bernardo M Borrelli M Lanza M . New factor to improve reliability of the clinical history method for intraocular lens power calculation after refractive surgery. J Cataract Refract Surg. (2010) 36:2123–8. 10.1016/j.jcrs.2010.07.017
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De Bernardo M Capasso L Caliendo L Paolercio F Rosa N . IOL power calculation after corneal refractive surgery. Biomed Res Int. (2014) 2014:658350. 10.1155/2014/658350
5.
De Bernardo M Cione F Capasso L Coppola A Rosa N . A formula to improve the reliability of optical axial length measurement in IOL power calculation. Sci Rep. (2022) 12:18845. 10.1038/s41598-022-23665-0
6.
De Bernardo M Borrelli M Imparato R Cione F Rosa N . Anterior chamber depth measurement before and after photorefractive keratectomy. Comparison between IOLMaster and Pentacam. Photodiagnosis Photodyn Ther. (2020) 32:101976. 10.1016/j.pdpdt.2020.101976
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Auffarth GU Hyeck-Soo A Koch M Weindler J Merz P Daphna O et al . Implantation of an artificial endothelial layer for treatment of chronic corneal edema. Cornea. (2021) 40:1633–38. 10.1097/ICO.0000000000002806
Summary
Keywords
cornea, external disease, refractive surgery, keratoconjunctivitis, keratoconus
Citation
Capasso L, De Bernardo M and Borrelli M (2023) Editorial: Corneal disease: an update. Front. Med. 10:1181810. doi: 10.3389/fmed.2023.1181810
Received
07 March 2023
Accepted
28 March 2023
Published
17 April 2023
Volume
10 - 2023
Edited and reviewed by
Jodhbir Mehta, Singapore National Eye Center, Singapore
Updates
Copyright
© 2023 Capasso, De Bernardo and Borrelli.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Maddalena De Bernardo mdebernardo@unisa.it
This article was submitted to Ophthalmology, a section of the journal Frontiers in Medicine
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.