AUTHOR=Miccichè Francesco , Rizzo Gianluca , Casà Calogero , Leone Mariavittoria , Quero Giuseppe , Boldrini Luca , Bulajic Milutin , Corsi Domenico Cristiano , Tondolo Vincenzo 

TITLE=Role of radiomics in predicting lymph node metastasis in gastric cancer: a systematic review

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1189740

DOI=10.3389/fmed.2023.1189740

ISSN=2296-858X

ABSTRACT=Introduction: Gastric cancer (GC) is an aggressive and clinically heterogeneous tumor, and a better risk stratification of lymph node metastasis (LNM) could lead to personalized treatments. The role of radiomics in the prediction of nodal involvement in GC is not already systematically assessed. Aim of this study is to assess the role of radiomics in the prediction of LNM in GC. 
Methods: A PubMed/MEDLINE systematic review was conducted to assess the role of radiomics in LNM, inclusion criteria were: i. original articles, ii. articles regarding radiomics, iii. article regarding LNM prediction in GC. All articles were selected and analyzed by a multidisciplinary board of two radiation oncologists and one surgeon, under the supervision of one radiation oncologist, one surgeon, and one medical oncologist. 
Results: A total of 171 studies were obtained using the mentioned search strategy on PubMed. After the complete selection process, a total of 20 papers were considered eligible for the analysis of the results. Radiomics methods were applied in GC to assess the LNM risk; number of patients, imaging modalities, type of predictive models, number of radiomics features, TRIPOD classification and performances of the models were reported. 
Conclusions: Radiomics seems to be a promising approach to evaluate the risk of LNM in GC. Further and larger studies are required to evaluate the clinical impact of the inclusion of radiomics in a comprehensive decision support system for GC.