AUTHOR=Lassoued Najoua , Alaya Wafa , Arfa Sondos , Korbi Mouna , Lassoued Ines , Amor Soumaya Ben , Zaouali Fatma , Farhat Zayneb , Chelly Jihen , Habib Sfar Mohamed 

TITLE=A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1196041

DOI=10.3389/fmed.2023.1196041

ISSN=2296-858X

ABSTRACT=The Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome can be potentially life-threatening .The diagnosis is sometimes difficult since the clinical manifestations may be incomplete or nonspecific .Insulinoma is a rare neuroendocrine tumour of the pancreas. Medical therapy may be needed when surgery is contraindicated, delayed or refused. Diazoxide is widely used to control hypoglycemia in patients with insulinoma.We report a clinical case of an insulinoma in a 85-year-old patient treated with diazoxide with a fatal outcome due to a delayed diagnosis of a DRESS syndrome. This is the first case of DRESS syndrome reported after using diazoxide for insulinoma treatment in our knowledge.