AUTHOR=Dang Si-Wen , Gao Lei , Li Yu-Jun , Zhang Ruo , Xu Jing 

TITLE=Metabolic characteristics of non-obese and obese metabolic dysfunction-associated fatty liver disease in type 2 diabetes mellitus and its association with diabetic peripheral neuropathy and diabetic retinopathy

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1216412

DOI=10.3389/fmed.2023.1216412

ISSN=2296-858X

ABSTRACT=To assessed metabolic characteristics of non-obese metabolic dysfunction-associated fatty liver disease (MAFLD) compared with obese MAFLD and the relationship of MAFLD with diabetic peripheral neuropathy and diabetic retinopathy in Type 2 diabetes mellitus (T2DM) patients.Methods: Data were obtained from 536 T2DM patients(355 females, 181 males; aged 58.2 ± 12.0 years). We explored the difference of clinical characteristics between obese MAFLD (body mass index ≥ 25 kg/m 2 ) and non-obese MAFLD (body mass index < 25 kg/m 2 ) in T2DM patients. One-way analysis of variance (ANOVA) was used to compare the means of continuous variables and the Chi-square test was used to compare the differences in frequency of categorical variables. Logistic regression models were adopted to calculate odds ratios.The prevalence of MAFLD in hospitalized Chinese T2DM patients was calculated at 42.7%. Compared with controls in the same weight group, both obese and non-obese MAFLD patients had higher levels of body mass index (BMI), waist circumference, triglyceride, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, younger age, higher prevalence of hyperlipidemia and shorter duration of T2DM and lower incidence of diabetic retinopathy. High BMI and triglyceride were independent risk factors of MAFLD, in both non-obese and obese participants in T2DM. Uric acid levels were positively correlated with MAFLD risk only in non-obese subjects, but not in obese subjects. In non-obese patients with T2DM, negative correlation between the prevalence of MAFLD and diabetic retinopathy was found.Even in non-obese patients with T2DM, BMI was found to be an independent risk factors of MAFLD. It support a more structured, risk-factor-based approach in MAFLD management, particularly for patients with T2DM. Non-obese MAFLD has unique results in metabolic characteristics and the correlation with diabetic retinopathy and diabetic peripheral neuropathy, Which should be further explored.