AUTHOR=Lan Kai-Yen , Le Puo-Hsien , Chiu Cheng-Tang , Chen Chien-Chang , Yeh Yuan-Ming , Cheng Hao-Tsai , Kuo Chia-Jung , Chen Chyi-Liang , Chen Yi-Ching , Yeh Pai-Jui , Chiu Cheng-Hsun , Chang Chee-Jen 

TITLE=Fecal microbiota transplantation for treatment of refractory or recurrent Clostridioides difficile infection in Taiwan: a cost-effectiveness analysis

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1229148

DOI=10.3389/fmed.2023.1229148

ISSN=2296-858X

ABSTRACT=Background: Compared to antibiotic treatment, fecal microbiota transplantation (FMT) is a more effective treatment for refractory or recurrent CDI (rCDI). Patients with inflammatory bowel disease (IBD) have a higher incidence of CDI and worse outcomes. There has been no study from Asia to evaluate the cost-effectiveness of FMT for overall rCDI patients and rCDI patients with IBD.We applied a Markov model with deterministic and probabilistic sensitivity analyses to evaluate cost and effectiveness of different treatments for rCDI patients with a time horizon of one year from the payer's perspective. We compared the cost and clinical outcomes of FMT through colonoscopy to two antibiotics (vancomycin and fidaxomicin) using data from Chang