AUTHOR=Mori Tatsuhiko , Namikawa Kenjiro , Yamazaki Naoya , Kiniwa Yukiko , Yamasaki Osamu , Yoshikawa Shusuke , Inozume Takashi , Kato Hiroshi , Nakai Yasuo , Fukushima Satoshi , Takenouchi Tatsuya , Maekawa Takeo , Matsushita Shigeto , Otsuka Atsushi , Nomura Motoo , Baba Natsuki , Isei Taiki , Saito Shintaro , Fujimoto Noriki , Tanaka Ryo , Kaneko Takahide , Kuwatsuka Yutaka , Matsuya Taisuke , Nagase Kotaro , Onishi Masazumi , Onuma Takehiro , Nakamura Yasuhiro 

TITLE=Efficacy of salvage therapies for advanced acral melanoma after anti-PD-1 monotherapy failure: a multicenter retrospective study of 108 Japanese patients

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1229937

DOI=10.3389/fmed.2023.1229937

ISSN=2296-858X

ABSTRACT=Background: Anti-programmed cell death protein 1 (PD-1) monotherapy is one of the standard systemic therapies for advanced melanoma; however, the efficacy of salvage systemic therapies after PD-1 monotherapy failure (PD-1 MF), particularly in acral melanoma (AM), the main clinical melanoma type in Japanese patients, is unclear. This study aimed to investigate the efficacy of salvage systemic therapies in Japanese patients with AM after PD-1 MF.insignificant. The OS in the nivo/ipi group was higher in the palm and sole groups than in the nail apparatus group (median: not reached vs. 8.7 months, P<0.001). Cox multivariate analysis demonstrated that nail apparatus melanoma independently predicted unfavorable PFS and OS (P=0.006 and 0.001). The total OS (from PD-1 monotherapy initiation to death/last follow-up) was insignificant between the groups.Conclusions: Nivo/ipi was not more effective than cytotoxic chemotherapy and ipilimumab after PD-1 MF in patients with advanced AM. The prognosis after PD-1 MF would be poorer for nail apparatus melanoma than for palm and sole melanoma.