AUTHOR=Cinar Fadime , Bulbuloglu Semra TITLE=Comparison of case and control groups in terms of postoperative complications, outcomes, and survival in total hip arthroplasty patients with and without COVID-19 JOURNAL=Frontiers in Medicine VOLUME=Volume 10 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1231655 DOI=10.3389/fmed.2023.1231655 ISSN=2296-858X ABSTRACT=Introduction: Total Hip Arthroplasty (THA) is not performed worldwide as an emergency surgical procedure and has often been postponed during the COVID-19 pandemic. The hypothesis of this study was that COVID-19 caused the extra burden and mortality of THA patients. It was aimed in the study to investigate the problems caused by comorbid COVID-19 in addition to the current clinical status in patients who had undergone THA. Material and Methods: We conducted the study as a case-control group study with the participation of patients with COVID-19 and without COVID-19 who had undergone THA and hospitalized in orthopedics clinic and intensive care unit at a research and training hospital. In the analysis of the data, IBM Statistical Package for Social Sciences 25.0 was employed.Results: 291 patients who had undergone THA were included in the study. 161 patients with COVID-19 constituted the control group, and 130 patients without COVID-19 constituted the case group. It was determined in the study that THA patients with COVID-19 had higher rates of nausea, vomiting, diarrhea, musculo-articular pain, and headache compared to those without COVID-19, and the difference was statistically significant (p<0.01). 17.7% of the patients with COVID-19 died, and delirium developed in 35.4%. The difference between the case group and the control group was statistically significant in terms of delirium and death (p<0.01).Discussion: COVID-19 increases the risk of delirium and death in THA patients, as well as extending hospital stay process. It should be remembered that the pandemic is not over yet, and that despite vaccination, it continues to have its devastating effects felt, especially on individuals in advanced age.