AUTHOR=Demlova Regina , Kozakova Sarka , Rihacek Michal , Buckova Dana , Horska Katerina , Wiewiorka Ondrej , Boucek Lubos , Selingerova Iveta , Podborska Martina , Korberova Alena , Mikuskova Alena , Starha Jiri , Benovska Miroslava , Radina Martin , Richter Michal , Zdrazilova Dubska Lenka , Valik Dalibor 

TITLE=Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1236948

DOI=10.3389/fmed.2023.1236948

ISSN=2296-858X

ABSTRACT=Background: Assessment of kidney function in emergency settings is essential across all medical subspecialties. Daily assessment of patient creatinine results from emergency medical services showed that some deviated from expected values, implying drug-related interference.

Methods: Real-time clinical evaluation of an enzyme method (Roche CREP2) in comparison to Jaffé gen. 2 method (Roche CREJ2) was performed. During the period of December 2022 and January 2023 we analyzed 8498 patient samples, where 5524 were heavily medicated STAT patient specimens, 500 were pediatric specimens and 2474 were from a distant general population in a different region using the same methods.

Results: In 109 out of 5524 hospital specimens (1,97%, p<0,001) the CREP2 value was apparently (25% or more) lower than CREJ2. Suspect interfering medication was found in a sample of 43 out of 46 reviewed patients where medication data were available. This phenomenon was not observed in a general population.
	
Conclusions: In a polymedicated urgent care hospital population, a creatinine enzyme method produces unreliable results, apparently due to multiple drug-related interferences.