AUTHOR=Soria Rivas Ainara , Bea-Ardebol Sonia , Vida Navas Elena , Muñoz-Arrones Óscar M. , Cabañas-Montero Luis Jacobo , Mena-Mateos Antonio , López-Campos Fernando , Corral Moreno Sara , Pérez-Muñoz Israel , González Lizan Fausto , Sanz Pascual María , Serrano Domingo Juan Jose TITLE=Treatment of metastatic squamous cell carcinoma arising in sacrococcygeal pilonidal sinus: a case report series JOURNAL=Frontiers in Medicine VOLUME=Volume 10 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1248894 DOI=10.3389/fmed.2023.1248894 ISSN=2296-858X ABSTRACT=Cutaneous squamous cell carcinoma arising in a pilonidal sinus is a very rare entity, with an estimated 100 cases reported in the literature, the vast majority of which are localized. Metastatic disease or disease that requires systemic treatment is even rarer, which represent a therapeutic challenge. In this sense, we aim to share our experience as multidisciplinary team in the treatment of this entity, at the same time that we try to summarize the evidence published to date. To the best of our knowledge, this is the largest series published to