AUTHOR=Wang Jun , Ma Liping 

TITLE=Tuberculosis patients with special clinical conditions treated with contezolid: three case reports and a literature review

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1265923

DOI=10.3389/fmed.2023.1265923

ISSN=2296-858X

ABSTRACT=Background: Contezolid is a noval oxazolidinone antibacterial agent, but there have been no reports of any pertinent clinical studies for the treatment of tuberculosis (TB). This was the first report of three TB patients who were successfully treated with contezolid.
Case Presentation: One case was TB complicated with myelosuppression syndrome. One case was drug-resistant TB complicated with cirrhosis and anemia. And another case with drug-resistant TB complicated with liver transplantation developed severe anemia after linezolid treatment. Following contezolid therapy, the three patients' symptoms essentially got better, and no adverse reactions were observed. The chest computed tomography (CT) examination also indicated that the therapeutic effect of this anti-TB regimen was in line with expectations.
Conclusion: Contezolid showed good efficacy and fewer side effects in the treatment of TB. It may be a promising treatment drug for TB.