AUTHOR=Zhang Shuai , Mi Jinhua , Ge Shengmei , Wang Guoqiang , Zhou Zhongyou , Zhao Yantao , Zhao Yan 

TITLE=Analysis of clinical characteristics and factors influencing herpes simplex virus keratitis

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1267783

DOI=10.3389/fmed.2023.1267783

ISSN=2296-858X

ABSTRACT=Objective: To investigate the clinical characteristics and influencing factors of herpes simplex virus keratitis. 
Methods: Patients with herpes simplex virus keratitis who came to our hospital from January 2018 to June 2022 were selected and divided into good prognosis group and poor prognosis group according to their prognosis. The clinical data of the two groups were compared, and univariate/multivariate Logisitic regression was used to analyze the influencing factors of poor prognosis of herpes simplex virus keratitis.
Results: One-way analysis of variance showed that compared with the good prognosis group, the poor prognosis group had more elderly patients and a longer course of disease, and the difference was statistically significant (P < 0.05). There were significant differences in the types of patients between the two groups (P < 0.05). Univariate logistic regression analysis also showed that age (≥65 years) (OR: 1.557, 95%CI: 1.081-2.183, P < 0.05), course of disease (> 7 months) (OR: 1.303, 95%CI: 1.003-1.829, P < 0.05), epithelial type (OR: 2.321, 95%CI: 1.198-4.321, P < 0.05) and stromal type (OR: 2.536, 95%CI: 1.672-3.871, P < 0.05) were risk factors for poor prognosis. Multivariate logistic regression analysis showed that age (≥65 years) (OR: 1.656, 95%CI: 1.168-2.357, P < 0.05)and course of disease (> 7 months) (OR: 1.461, 95%CI: 1.031-2.001, P < 0.05) were independent risk factors for the prognosis of herpes simplex keratitis. 
Conclusion: The clinical symptoms of herpes simplex virus keratitis include corneal opacity, corneal posterior elastic layer folds, corneal infiltration, posterior corneal mass, corneal edema, eye pain. Age and course of disease are important factors affecting the prognosis of herpes simplex virus keratitis.