AUTHOR=Rubinstein Artem , Kudryavtsev Igor , Malkova Annа , Mammedova Jennet , Isakov Dmitry , Isakova-Sivak Irina , Kudlay Dmitry , Starshinova Anna 

TITLE=Sarcoidosis-related autoimmune inflammation in COVID-19 convalescent patients

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1271198

DOI=10.3389/fmed.2023.1271198

ISSN=2296-858X

ABSTRACT=Currently, there are a large number of reports about the development of autoimmune pathology after COVID-19. Also, there have been cases of sarcoid-like granulomas in convalescents as a part of the post-COVID-19 syndrome. Since one of the etiological theories of sarcoidosis considers it to be an autoimmune disease, we decided to study changes in the adaptive humoral immune response in sarcoidosis and SARS-CoV-2 infection and find out, can COVID-19 provoke the development of sarcoidosis. This review discusses histological changes in lymphoid organs in sarcoidosis and COVID-19, changes of B cells subpopulations, Tfollicular helper cells (Tfh) and T-follicular regulatory cells (Tfr), and analyzes various autoantibodies detected in these pathologies. Based on the data studied, we concluded that SARS-CoV-2 infection can cause the development of autoimmune pathologies, in particular, contribute to the onset of sarcoidosis in convalescents.