AUTHOR=Wan Ji-Xiang , Li Xue-Chao , Zeng Si-Si , Li Yu-Qian , Wang Fang-Jun 

TITLE=Comparison of intravenous butorphanol vs. tramadol for post-spinal anesthesia shivering: a meta-analysis and systematic review

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1271664

DOI=10.3389/fmed.2023.1271664

ISSN=2296-858X

ABSTRACT=BACKGROUND: Patients often occur shivering after spinal anesthesia.In recent years, more and more studies have compared the efficacy and side effects of intravenous butorphanol and tramadol in the treatment of shivering after spinal anesthesia. Therefore, we conducted a mate-analysis and systematic review to compare the efficacy and side effects of butorphanol versus tramadol in the treatment of shivering after spinal anesthesia.: PubMed, Cochrane Library, and Embase were searched for randomized controlled trials (RCTs) from inception to December 30, 2022, comparing the effects of butorphanol versus tramadol for the control of shivering after spinal anesthesia. Data assessment and collection were analyzed by Review Manager 5.4 software.Five randomized controlled trials involving 302 adult patients were included in this meta-analysis. The results showed that butorphanol has a shorter time to cease shivering (standardized mean difference (SMD) = -0.53; 95% confidence interval (CI) [-0.89, -0.17], P=0.004, I 2 =0%), higher rate of cessation of shivering within 1 minute after giving study drugs (relative risk (RR), 1.69; 95% CI [1.15,2.48], P=0.008, I 2 =0%), higher incidences of sedation (RR, 2.98; 95% CI [2.11,   4.21], P＜0.00001, I 2 =0%), compared with tramadol.In the treatment of shivering after spinal anesthesia, butorphanol has a shorter onset time and a higher rate of cessation of shivering within 1 minute after giving study drugs than tramadol.