AUTHOR=Sun Wenwu , Zhao Bing , Li Jiaoyan , Wang Yihui , Qi Xing , Ning Ning , Sun Silei , Li Mengjiao , Yao Yi , Ni Tongtian , Ma Li , He Juan , Huang Jun , Yang Zhitao , Chen Ying , Sheng Huiqiu , Mao Enqiang 

TITLE=Effect of high-dose intravenous vitamin C therapy on the prognosis in patients with moderately severe and severe acute pancreatitis: protocol of a prospective, randomized, double-blinded, placebo-controlled study

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1278167

DOI=10.3389/fmed.2023.1278167

ISSN=2296-858X

ABSTRACT=Intr oduction: Acute pancreatitis is a common gastrointestinal disease. The mortality of patients suffered with severe acute pancreatitis (SAP) remains high. It is unclear whether high dose intravenous vitamin C (HDIVC) therapy could improve the prognosis of these patients. The current prospective, randomized, double-blinded, placebo-controlled study will explore the effect of high This is a provisional file, not the final typeset article dose intravenous vitamin C therapy on the prognosis in patients with moderately severe and severe acute pancreatitis.Methods and design: 418 participants with moderately severe and severe acute pancreatitis that satisfy the eligible criteria will be randomized 1:1 to receive treatment with HDIVC (200mg/kg/24h) or placebo (saline) for 7 days. The primary outcome is 28 days mortality in these patients. The secondary outcomes include organ functions and interventions, laboratory test, healthcare and 90 days mortality.