AUTHOR=Bender Sascha T. , Zeremski Vanja , Wiech Thorsten , Mertens Peter R. , Gross Christian 

TITLE=Case report: Acute kidney injury as the initial manifestation of chronic lymphocytic leukemia/small lymphocytic lymphoma

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1279005

DOI=10.3389/fmed.2023.1279005

ISSN=2296-858X

ABSTRACT=Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder often diagnosed after incidental finding of leukocytosis. Renal involvement is usually clinically silent. Symptomatic renal impairment due to CLL/small lymphocytic lymphoma (SLL) cell infiltration in the kidney tissue is uncommon and acute kidney injury (AKI) as presenting feature is scarce. In this case report we describe a patient with AKI, due to CLL/SLL infiltration as presenting feature. Our report underlines the possibility of kidney injury as first evident symptom of CLL/SLL. Kidney biopsy is the mainstay in these cases to establish diagnosis. Treatment with zanubrutinib resulted in improved kidney function.