AUTHOR=Andel Peter M. , Diamantopoulos Andreas P. , Myklebust Geirmund , Haugeberg Glenn 

TITLE=Vasculitis distribution and clinical characteristics in giant cell arteritis: a retrospective study using the new 2022 ACR/EULAR classification criteria

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1286601

DOI=10.3389/fmed.2023.1286601

ISSN=2296-858X

ABSTRACT=Giant cell arteritis (GCA) is the most common vasculitis of the elderly. In recent years advanced imaging has to a certain extent replaced temporal artery biopsy (TAB) to aid diagnosis in many institutions and helped to identify three major phenotypes of GCA, namely cranial-GCA (c-GCA), large vessel non-cranial GCA (LV-GCA) and a combination of these two patterns called mixed-GCA which all show different clinical patterns. Recent «2022 American College of Rheumatology (ACR) / European Leage against Rheumatism (EULAR) classification criteria» respect the changing conception and clinical practice during the last two decades. In this cohort study we present vasculitis distribution and baseline characteristics using «2022 ACR / EULAR classification criteria» as well as «EULAR core data set».In this retrospective study from Southern Norway, we identified all patients diagnosed with GCA between 2006 and 2019 in our single center fast-track-clinic (FTC). We included all patients that were examined using ultrasound (US) of cranial as well as non-cranial large vessels at diagnosis to depict vascular distribution. «EULAR core data set», «ACR 1990» and «2022 ACR/EULAR classification criteria» were used to characterize the cohort.Seventy-seven patients were diagnosed with GCA at our institution in the aforementioned period. Seventy-one patients (92.2%) were diagnosed with the help of US and included in the further analysis. «2022 ACR/EULAR classification criteria» allocated 69 patients (97.2%), while «ACR 1990 classification criteria» allocated 49 patients (69.0%) in our cohort as having GCA. Mixed-GCA was the most common type in 33 patients (46.5 %). Weight-loss was significantly more common in patients with large vessel non-cranial vasculitis in LV-GCA and mixed-GCA. Headache on the other hand was significantly more common in patients with involvement of cranial vessels.Mixed-GCA was the most common form of GCA in our cohort. In our study «2022 ACR /EULAR classification criteria» seem to be a more useful tool compared to the old «ACR 1990 classification criteria» to allocate GCA patients diagnosed and treated at our US based FTC as having GCA.