AUTHOR=Au Heng-Kien , Liu Chi-Feng , Chien Li-Wei 

TITLE=Clinical factors associated with subsequent surgical intervention in women undergoing early medical termination of viable or non-viable pregnancies

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1188629

DOI=10.3389/fmed.2024.1188629

ISSN=2296-858X

ABSTRACT=Mifepristone-misoprostol treatment for medical abortion and miscarriage are safe and effective. This study aimed to assess clinical factors associated withfor subsequent surgical intervention after medical termination of early viable or non-viable pregnancy.This retrospective, single-center study included women who underwent medical abortion at Taipei Medical University was conducted in a single university hospital between January 2010 and December 2019. A total of 1561 subjects, with 1080 viable and 481 non-viable pregnancies, who were treated with oral mifepristone 600 mg followed by misoprostol 600 mg 48 hours later were included. Data of all pregnancies and medical termination of pregnancy were evaluated using regression analysis. The main outcome was successful termination of pregnancy. The success rate of medical abortion was comparable in women with viable and non-viable (92.13% vs. 92.93%) pregnancies. Besides the retained tissue, more evidence of existingongoing pregnanciesy with ultrasonographic findings wereas found in the non-viable pregnancy group than in the viable pregnancy group (29.4% vs. 14.1%, P=0.01105).Multivariate analysis showed that previous delivery was an independent risk factor for failed medical abortion among all included cases. In women with viable pregnancy, longer gestational age (adjusted odds ratio (aOR): 1.483, 95% confidence interval (CI): 1.224-1.797, p<0.001) and previous Cesarean delivery (aOR: 2.177, 95% CI:1.167-40.62, p=0.014) were independent risk factors for failed medical abortion.Number of Cesarean deliveries (aOR: 1.448, 95% CI: 1.029-2.039, p=0.034) was an independent risk factor for failed medication abortion in women with non-viable pregnancies. This is the first cohort study to identify risk factors for subsequent surgical intervention in women with viable or non-viable pregnancies who had undergone early medically induced abortions. The success rate of medical abortion is comparable in women with viable and non-viable pregnancies. Previous delivery is an independent risk factor for failed medical abortion. Clinical follow-up may be necessary for women who are at risk of subsequent surgical intervention.