AUTHOR=Sun Yongtao , Zhang Xiaoning , Zhang Min , Guo Yongle , Sun Tao , Liu Mengjie , Gao Xiaojun , Liu Yang , Gao Zhongquan , Chen Lina , Du Xiaoyan , Wang Yuelan 

TITLE=Preliminary investigation of the effect of non-cardiac surgery on intraoperative islet and renal function: a single-center prospective cohort study

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1235335

DOI=10.3389/fmed.2024.1235335

ISSN=2296-858X

ABSTRACT=The effect of different noncardiac surgical methods on islet and renal function remains unclear. We conducted a preliminary investigation to determine whether different surgical methods affect islet function or cause further damage to renal function. Methods: In this prospective cohort study, the clinical data of 63 adult patients who underwent noncardiac surgery under general anesthesia were evaluated from February 2019 to January 2020. Patients were divided into the abdominal surgery group, the laparoscopic surgery group and the breast cancer surgery group. The primary outcome was the difference between the effects of different surgical methods on renal function. Results: Islet and renal function were not significantly different between the groups. The correlation analysis showed that HCT and Hb were negatively correlated with fasting plasma glucose (FPG) (P < 0.05), MAP was positively correlated with C-peptide (P < 0.05), and HCT and Hb were positively correlated with serum creatinine (SCr) (P < 0.05). Fasting insulin (FINS) and C-peptide were negatively correlated with SCr (P < 0.05); Homa Model-insulin resistance (HOMA-IR) was positively correlated with SCr (P < 0.05). FINS, C-peptide, HOMA-IR and Homa Model-β (HOMAβ) were positively correlated with cystatin C (Cys C) (P < 0.05).  Conclusion: FINS, C-peptide, and HOMA-IR had positive effects on beta-2-microglobulin (β2-MG). FINS, C-peptide, and HOMA-IR were positively correlated with Cys C and β2-Mg. While FINS and C-peptide were negatively correlated with SCr, HOMA-IR was positively correlated with SCr.