AUTHOR=Olguín-Ortega Andrea , Figueroa-Damian Ricardo , Palafox-Vargas Martha Leticia , Reyes-Muñoz Enrique 

TITLE=Risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitis

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1242962

DOI=10.3389/fmed.2024.1242962

ISSN=2296-858X

ABSTRACT=This historical cohort study aimed to assess the risk of adverse perinatal outcomes (APOs) in pregnant women with histologic chorioamnionitis (HCA). During the study period, all placentas were evaluated by a perinatal pathologist, and all women with HCA were included. Two groups were integrated: 1) women with clinical chorioamnionitis (CCA) and 2) women with subclinical chorioamnionitis (SCCA). Additionally, we conducted a secondary analysis to compare the prevalence of APOs among stage 1, 2 and 3 of HCA and the risk of APOs between grades 1 and 2 of HCA. The APOs analyzed were preterm birth, stillbirth, neonatal weight <1500g, neonatal sepsis. Relative risk with 95% confidence interval was calculated. The study included 41 cases of CCA and 270 cases of SCCA. The mean gestational age at diagnosis and birth was 30.2 ± 5.4 weeks and 32.5 ± 5.1 weeks, for group 1 and 2, respectively. The study also found that women with HCA stage 3 and grade 2 had a higher prevalence and risk of adverse perinatal outcomes. The findings of this study suggest the importance of placental histological study to excluded SCCA, which represents a significant risk to both maternal and neonatal health, contributing to high morbidity and mortality.