AUTHOR=Jin Xiaohan , Yang Yu , Chen Guangmei , Shao Yue , Liu Chang , Li Rong , Liu Yazhuo , Zhang Lichuan 

TITLE=Correlation between body composition and disease severity in patients with chronic obstructive pulmonary disease

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1304384

DOI=10.3389/fmed.2024.1304384

ISSN=2296-858X

ABSTRACT=Background: Body composition changes are important extrapulmonary manifestations in COPD patients. This study aimed to investigate the characteristics of body composition in patients with COPD, and its correlation with disease severity.Methods: A total of 105 COPD patients admitted to Zhongshan Hospital affiliated to Dalian University, from May 1 2021 to January 31 2023, were included as the COPD group, and 105 subjects without COPD were enrolled as the control group during the same period. According to the GOLD comprehensive assessment indicators, COPD patients were divided into groups: the degree of pulmonary function airflow limitation was grouped according to FEV1%pred; clinical symptoms were grouped according to mMRC scores and CAT scores; the risk of acute exacerbation was divided into low risk and high risk groups.Body composition was measured by BIA.(1) Concerning body composition, the BMI, FFMI, and PhA of COPD patients were lower than those of the control group., ECW/TBW and ECW/ICW were higher than those of the control group, and the difference was statistically significant (p ＜ 0.05). (2) There were differences in body composition among COPD patients with different severity of disease: FFMI and PhA in the mild/moderate airflow limitation group were higher than those in the severe/very severe airflow limitation group. According to mMRC scores classification, the FFMI and PhA of the less symptomatic group were higher than those of the more symptomatic group, and ECW/TBW and ECW/ICW were lower than those of the more symptomatic group. According to CAT scores classification, FFMI and PhA in the mild/moderate disease group were higher than those in the severe/very severe disease group. The FFMI of the low-risk group was higher than that of the high-risk group, and ECW/TBW was lower than that of the high risk group. (3) Correlation analysis between body composition and disease severity indicators showed that FFMI and PhA were negatively correlated with mMRC scores and CAT scores, and positively correlated with FEV1%pred.ECW/TBW ratio and ECW/ICW ratio were positively correlated with mMRC scores and CAT scores, and negatively correlated with FEV1%pred, and the difference was statistically significant (p < 0.05).