AUTHOR=Ginevičienė Valentina , Pranckevičienė Erinija , Kilaitė Justina , Mastavičiūtė Asta , Dadelienė Rūta , Jamontaitė Ieva Eglė , Letukienė Austėja , Ahmetov Ildus I. , Alekna Vidmantas 

TITLE=Bibliometric and scientometric analysis on biomarkers and molecular mechanisms for physical frailty and sarcopenia

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1326764

DOI=10.3389/fmed.2024.1326764

ISSN=2296-858X

ABSTRACT=The impact of physical frailty and sarcopenia (PFS) on the well-being of older people and on the sustainability of healthcare systems has instigated intense research on the pathophysiology and molecular mechanisms of these conditions. Despite the fact that several biomarkers have been proposed, none of them have been shown to capture the complexity of PFS, which indicates that there is still a need for an understanding of the possible biomarker candidates. The aim of this study was to identify the current research hotspots, status, and trends in the field of biomarkers and molecular mechanisms for PFS. The bibliometric analyses were performed using VOSviewer (version 1.6.18) and open source software platform Cytoscape v.3.9 (for visualizing and constructing a network of keywords). Data of publications (from 1997 to 2023) related to biomarkers and molecular mechanisms of PFS were obtained (in May 2023) from the database of Science Citation Index Expanded of Web of Science, Scopus, and PubMed. The keywords obtained from the Scopus database were used to perform a meaningful keyword analysis. We used Cytoscape to construct a network of keyword relationships. In this study, we present biomarker keywords for PFS in relation to other keywords potentially designating processes and mechanisms and reveal the biomarker identities and current contexts in which these biomarker identities are discussed. In conclusion, over the last years, increasing research interest in field of PFS has been focused on the inflammatory process and probably will be focused on myokines, a set of cytokines and small proteins that are synthetized and released by skeletal muscles in response to physical activity. Moreover, proteomic and genetic markers are deeply involved in PFS.