AUTHOR=Falasca Katia , Vetrugno Luigi , Borrelli Paola , Di Nicola Marta , Ucciferri Claudio , Gambi Alessandra , Bazydlo Magdalena , Taraschi Giorgia , Vecchiet Jacopo , Maggiore Salvatore Maurizio 

TITLE=Antimicrobial resistance in intensive care patients hospitalized with SEPSIS: a comparison between the COVID-19 pandemic and pre-pandemic era

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1355144

DOI=10.3389/fmed.2024.1355144

ISSN=2296-858X

ABSTRACT=Introduction: Coronavirus disease 2019 (COVID-19) is a highly contagious viral illness caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It has had a dramatic effect on the world, resulting in millions of deaths worldwide and causing drastic changes in daily life. A study reported that septic complications were associated with high mortality in COVID-19 patients. The aim of this study wereThis study aimed to evaluate how the COVID-19 pandemic changed the pre-pandemic and post-pandemic prevalence of sepsis in ICUs and to to evaluate the different risk factors associated with mortality and the different diffusion of microorganisms and their resistance. Materials and Methods: We carried out a single center centre retrospective observational clinical study that observed observed all the patients in in the ICU of the SS Annunziata Hospital in Chieti (Italy) who had a diagnosis of sepsis and presented a bacterial isolate from blood culture. The diagnosis of sepsis was made in accordance withby SEPSIIS III criteria. We enrolled all in-patients in the ICU from January 2018 to December 2021. We divided the patients into three groups: (1) Np (Non Pandemic period) hospitalized in 2018-2019, (2) Pp (Pandemic Period)-COVID hospitalized in 2020-2021 with a diagnosis of COVID-19, and (3) Pp noCOVID patients hospitalized 2020-2021 without a diagnosis of COVID-19.