AUTHOR=Yang Xiaobo , Ouyang Yaqi , Xu Jiqian , Shang You 

TITLE=Protocol for a systematic review and individual participant data meta-analysis of optimizing oxygen therapy in critically ill patients

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1356557

DOI=10.3389/fmed.2024.1356557

ISSN=2296-858X

ABSTRACT=Background: Oxygen therapy is a cornerstone treatment of critically ill patients in the intensive care unit (ICU). Whether lower oxygenation therapy brings superior survival outcomes to higher oxygenation therapy is unknown.Methods: We will search electronic databases: Pubmed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials (CEN-TRAL), International Clinical Trials Registry Platform (ICTRP), and ClinicalTrials.gov from inception to January 1st, 2024. Two authors will independently screen for all eligible clinical studies. Emails will be sent for individual participant data. The statistical analyses will be conducted by STATA 15.0 software.We will evaluate the efficacy of lower oxygenation therapy compared with higher oxygenation therapy based on individual participant data.This study will offer clinical evidence for oxygen therapy in ICU patients.