AUTHOR=Alfonso Claudia P. , N’Jambong Guy B. , Magdy Alaa , Di Trapani Laura , Kuwana Rutendo , Kahsay Abraham G. , Maïga Diadié , Ossei-Agyeman-Yeboah Sybil N. A. , Djitafo Fah Aimé B. , Ndomondo-Sigonda Margareth 

TITLE=Identifying and costing common gaps in Central and West Africa pharmaceutical regulation

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1362253

DOI=10.3389/fmed.2024.1362253

ISSN=2296-858X

ABSTRACT=Background -Regulatory systems strengthening is crucial for catalyzing access to safe and effective medical products and health technologies (MPHT) for all. Identifying and addressing common regulatory gaps through regional approaches could be instrumental for the newly incepted African Medicines Agency. Aims -This original study sheds light on common gaps among ten national regulatory authorities (NRAs) and ways to address them regionally. Objectives -The study used NRA self-assessment outcomes to identify common gaps in four critical regulatory pillars and estimate the cost of addressing them from regional perspectives that aimed at raising the maturity level of regulatory institutions. Methods -A cross-sectional study, using the WHO Global Benchmarking Tool (GBT), was conducted between 2020 and 2021 with five NRAs from ECCAS and from ECOWAS member states that use French and Spanish as lingua franca. Results -The ten NRAs operated in a non-formal-to-reactive approach (ML1-2), which hinder their ability to assure the quality of MPHT and respond appropriately to public health emergencies. Common gaps were identified in four critical regulatory pillarsgood regulatory practices, preparedness for public health emergencies, quality management systems, and substandard and falsified medical productswith overall cost to address gaps estimated at US$3.3 million. Contribution -We elaborated a reproducible method to strengthen regulatory systems at a regional level to improve equitable access to assured-quality MPHT. Our bottom-up approach could be utilized by RECs to address common gaps through common efforts.