AUTHOR=Huong Nguyen Thi Kim , Long Bui , Doanh Le Huu , Thoai Tran Minh , Hang Nguyen Thi , Khoi Le , Nu Pham Thi 

TITLE=Associations of different inflammatory factors with atherosclerosis among patients with psoriasis vulgaris

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1396680

DOI=10.3389/fmed.2024.1396680

ISSN=2296-858X

ABSTRACT=Background: This study aimed to measure the associations between different inflammatory factors, namely interleukin (IL)-17A, tumor necrosis factor (TNF)-α, and high-sensitivity C-reactive protein (hs-CRP), and atherosclerosis in patients with psoriasis vulgaris. Method: A cross-sectional study was conducted at two hospitals in Hanoi, Vietnam. A total of 125 patients with psoriasis vulgaris and 50 healthy controls were recruited. Clinical characteristics and atherosclerosis were assessed. IL-17A, TNF-α, and hs-CRP levels were measured. Results: Psoriasis vulgaris patients with atherosclerosis had higher levels of hs-CRP (median = 1.22; interquartile range -IQR=0.34-12.11) and IL-17A (median = 1.30; IQR=0.43-4.28), but a lower level of TNF-α (median = 0.54; IQR=0.13-3.41) compared to those without atherosclerosis (p<0.05). Only LogIL-17A was positively related to atherosclerosis in psoriasis patients (Odds Ratio -OR = 2.16, 95% CI = 1.06-4.38, p<0.05). After excluding systemically treated patients, LogIL-17A and Log TNF-α were associated with the likelihood of atherosclerosis (p<0.05).This study suggests a link between elevated levels of IL-17A and TNF-α and subclinical atherosclerosis. Further investigation on a larger scale is required to establish the causality of this relationship.