AUTHOR=Carrozzi Marco , Morelli Maria Elisa , Cirino Mario , Maestro Alessandra , Paternuosto Gilda , Benericetti Giulia , Bennati Giada , Bin Maura , Flamigni Anna , Pigato Federico , Maximova Natalia , Barbi Egidio , Zanon Davide 

TITLE=Oral ATP treatment in alternating hemiplegia of childhood: a case report and review

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1433217

DOI=10.3389/fmed.2024.1433217

ISSN=2296-858X

ABSTRACT=Alternating hemiplegia of childhood (AHC) is a rare neurological disorder that usually manifests before 18 months of age and is characterized by recurrent, alternating episodes of hemiparesis with variable frequency and can last from a few minutes to several days. We present a case of AHC in a little girl carrying a sporadic mutation in the ATP1A3 gene (p.Glu815Lys) refractory to flunarizine and non-compliant to topiramate due to adverse effects treated with oral compound of adenosine-5′-triphosphate (ATP) capsules. Outcome was evaluated through the follow-up and side effects and safety were monitored regularly. Compounded drug showed effectiveness and safety. Indeed, during the four-year follow-up, with the dose of adenosine-5′-triphosphate gradually increasing up to 21 mg/kg, the patient showed a substantial benefit in controlling the frequency and duration of hemiplegic episodes and an improvement in neurological deterioration.