AUTHOR=Tan Shuai , Shang Mingyue , Masaki Yasufumi , Ni Jing , Da Yuwei , Sun Jing , Cao Yaofang , Su Li , Sun Wanling 

TITLE=Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1445971

DOI=10.3389/fmed.2024.1445971

ISSN=2296-858X

ABSTRACT=This case provides valuable information for identifying POEMS syndrome, especially when EMG results of peripheral neuropathy may suggest severe edema. It also highlights a specific rare disease typeatypical POEMS syndrome without polyneuropathy.  The patient, critically ill, presented with multiple rare diseases simultaneously, including POEMS syndrome, TAFRO syndrome, and Castleman disease, offering a valuable opportunity to improve disease identification.  Rapid diagnosis and treatment (using dexamethasone) was crucial in saving the patient's life. Continued improvement in quality of life was observed with ASCT after several courses of chemotherapy using the Rd regimen, and the prognosis remains favorable to date.