AUTHOR=Que Zenglong , Wu Mingsong , Lai Shujie , Wang Lei , Mu Zhiyong , Yang Jinhui , Xiong Wei , Hu Hong , Liu Aimin , An Xuan , Yu Haodong , Cao Qin , Zhang Yanmei , Luo Wenwen , Wang Jun , Chen Dongfeng , Liu Fuquan , Zhang Dazhi , Wen Liangzhi 

TITLE=Development and validation of a prognostic score for TIPS placement in patients with viral hepatitis cirrhosis-related portal hypertension: a multi-center retrospective study

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1456758

DOI=10.3389/fmed.2024.1456758

ISSN=2296-858X

ABSTRACT=Introduction: There is no established scoring model focus on viral hepatitis patients to predict the prognosis after transjugular intrahepatic portosystemic shunt (TIPS). We aimed to develop and validate a novel model based on the largest cohort for better prediction of both short-term (1 year) and long-term (3 years) postoperative prognosis after TIPS in viral hepatitis cirrhosis-related portal hypertension patients.
Methods: A total of 925 viral hepatitis cirrhosis-related portal hypertension patients underwent TIPS from nine hospitals were divided into the training and external validation cohorts. A novel Viral-associated Index of Post-TIPS score (VIPs) model was built after performing cox regression. We compared it with five previous models including Child-Pugh, MELD, ALBI, CCG and FIPS. Furthermore, Using X-tile software to stratify patients into low-medium-high risk groups.
Results: The VIP score model including age, ascites, albumin, prothrombin time, total bilirubin, and sodium for post-TIPS prognosis prediction. The model demonstrated a satisfying predictive efficiency in both discrimination and calibration, with an area under the curve of 0.781/0.774 (1-year/3-year) in the training cohort and 0.771/0.775 (1-year/3-year) in the external validation cohort, respectively. 
Discussion: We firstly developed and external validated a novel VIPs model for better prediction of both short-term and long-term postoperative prognosis after TIPS in Chinese patients with viral hepatitis cirrhosis-related portal hypertension.