AUTHOR=Safaei Farahnaz , Shahrokh Shabnam , Naderi Nosratollah , Rastegar Reyhaneh , Shamsi Alireza 

TITLE=Unveiling the efficacy of paroxetine and gabapentin in ulcerative colitis patients in remission with co-existing IBS-like symptoms: a single-blinded randomized clinical trial

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1468885

DOI=10.3389/fmed.2024.1468885

ISSN=2296-858X

ABSTRACT=This clinical trial is designed to explore the efficacy of paroxetine and gabapentin in alleviating functional gastrointestinal symptoms, anxiety, depression, and quality of life in patients with ulcerative colitis during the remission stage. 97 patients with ulcerative colitis in remission who had reported functional gastrointestinal symptoms enrolled in the study. patients Were measured in terms of quality of life, anxiety, depression, and IBS severity. One group received paroxetine at a dosage of 20 mg/day and the other group received gabapentin at a dosage of 100 mg/day in the first month and 300mg/day in the second and third months. the patients were followed up for 3 months. Anxiety (p<0.001), depression (p=0.012), and severity score levels (p=0.045) among patients in the paroxetine group were significantly lower compared to the gabapentin group following the intervention. Paired evaluation in each treatment group revealed a significant reduction in the paroxetine group while changes in the gabapentin group were not significant.Quality-of-life scores among patients in the paroxetine group were significantly higher compared to the gabapentin group following the intervention (p<0.001). The rate of improvement in gastrointestinal functional symptoms, anxiety, depression, and quality of life is significantly superior with paroxetine compared to gabapentin.