AUTHOR=Zhou Tianhan , Ni Zhongkai , Fan Hao , Huang Hai , Jin Haimin 

TITLE=Utilizing innovative two curves in nomogram

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1478603

DOI=10.3389/fmed.2024.1478603

ISSN=2296-858X

ABSTRACT=ObjectiveNomograms are valuable tools in clinical research for predicting patient outcomes. Understanding threshold values within these models is crucial for assessing the model’s effectiveness and practical application in clinical environments.MethodsWe developed two novel interpretive curves to enhance the utility of nomograms. These curves were designed to provide clear visualization of how clinical prediction models perform across various thresholds. The curves are applied to two case studies to demonstrate their practical application and efficacy.ResultsIn both examples, the novel curves successfully highlighted critical threshold values and revealed changes in prediction accuracy across these thresholds. This enhanced the understanding of the nomogram’s performance, providing clinicians with more informative decision-making tools.ConclusionsThe introduction of these interpretive curves allows for a more nuanced understanding of nomogram-based predictions, offering insights into threshold effects that can inform clinical decisions.