AUTHOR=Luo Xinyu , Lv Yufan , Yang Jinsai , Long Rou , Qiu Jieya , Deng Yuqi , Tang Guiyang , Zhang Chaohui , Li Jiale , Zuo Jianhong 

TITLE=Gamma delta T cells in cancer therapy: from tumor recognition to novel treatments

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1480191

DOI=10.3389/fmed.2024.1480191

ISSN=2296-858X

ABSTRACT=Traditional immunotherapies mainly focus on αβ T cell-based strategies, which depend on MHC-mediated antigen recognition. However, this approach poses significant challenges in treating recurrent tumors, as immune escape mechanisms are widespread. γδ T cells, with their ability for MHC-independent antigen presentation, offer a promising alternative that could potentially overcome limitations observed in traditional immunotherapies. These cells play a role in tumor immune surveillance through a unique mechanism of antigen recognition and synergistic interactions with other immune effector cells. In this review, we will discuss the biological properties of the Vδ1 and Vδ2 T subsets of γδ T cells, their immunomodulatory role within the tumor microenvironment, and the most recent clinical advances in γδ T cell-based related immunotherapies, including cell engaging strategies and adoptive cell therapy.