AUTHOR=Xiao Ping-Ping , Fan Wei , Chen Xu-Yan , Li Ke-Cong , Li Ting-Ting , Dong Zhi-Gao 

TITLE=MDA5-positive dermatomyositis without muscle weakness and rash: a case report and literature review

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1482350

DOI=10.3389/fmed.2024.1482350

ISSN=2296-858X

ABSTRACT=Melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (DM) is a rare systemic autoimmune disease associated with a high rate of mortality attributable to rapidly progressive interstitial lung disease. MDA5-positive DM is often complicated by a typical rash and muscle weakness. Herein, we describe a 50-year-old woman who presented with worsening pulmonary symptoms with an absence of typical clinical characteristics. We also review the treatments and prognosis made in similar cases, highlighting that closer attention should be paid to patients presenting with atypical DM, particularly when clinical manifestations such as rash and muscle weakness are not apparent.