AUTHOR=Xue Song , Chen Jiaqi , Shi Yuzhu , Zhang Lina , Chen Man , Sun Huipeng , Cao Xingyu , Wu Fang 

TITLE=Severe late onset capillary leak syndrome post allo-HSCT successfully treated by bevacizumab: a case report

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1483064

DOI=10.3389/fmed.2024.1483064

ISSN=2296-858X

ABSTRACT=This article describes a case of successful management of late-onset CLS occurring after allo-HSCT, employing bevacizumab as the therapeutic agent. Capillary leak syndrome (CLS) represents a critical complication arising from allogeneic hematopoietic stem cell transplantation (allo-HSCT). The prognosis for CLS remains considerably constrained. A targeted therapeutic approach targeting vascular endothelial growth factor (VEGF) offers a novel strategy for the management of CLS.