AUTHOR=Chen Chen , Huang Yizhuo , Shi Lei , Zhou Li , Zhou Shenao , Wan Hongjin , Yang Xiao , Zhao Jie 

TITLE=Allogeneic fibroblasts ameliorate intervertebral disc degeneration by reducing osteophytes in rabbits

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1488727

DOI=10.3389/fmed.2024.1488727

ISSN=2296-858X

ABSTRACT=Low back pain (LBP) was commonly induced by intervertebral disc degeneration (IVDD), which is accompanied by the loss of disc height and osteophyte generation. Cell-based therapy is a promising treatment for preventing the degeneration of interverbal disc. Here, we established a rabbits-derived fibroblast (Rab-Fib) which could be expanded in vitro. On puncture induced intervertebral disc degeneration (IVDD) rat models, Rab-Fib had significant therapeutic effects as X-ray, CT and MRI results indicated an exceptional mitigation of disc degeneration. Therefore, this study could be a foundation of further applying fibroblast into clinical trials.