AUTHOR=Yang Chunhong , Chen Yijing , Qian Changshun , Shi Fangmin , Guo You TITLE=The data-intensive research paradigm: challenges and responses in clinical professional graduate education JOURNAL=Frontiers in Medicine VOLUME=Volume 12 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1461863 DOI=10.3389/fmed.2025.1461863 ISSN=2296-858X ABSTRACT=With the widespread application of big data, artificial intelligence, and machine learning technologies in the medical field, a new paradigm of data-intensive clinical research is emerging as a key force driving medical advancement. This new paradigm presents unprecedented challenges for graduate education in clinical professions, encompassing multidisciplinary integration needs, high-quality faculty shortages, learning method transformations, assessment system updates, and ethical concerns. Future healthcare professionals will need not only to possess traditional medical knowledge and clinical skills, but also to master interdisciplinary skills such as data analysis, programming, and statistics. In response, this paper proposes a series of countermeasures, including curriculum reconstruction, faculty development, developing and sharing resources, updating the evaluation and assessment system, and strengthening ethics education. These initiatives aim to help clinical graduate education better adapt to this new paradigm, ultimately cultivating interdisciplinary talents in medical-computer integration.