AUTHOR=Nagarajan Gopinath , Rajasekaran Anandh , Nagarajan Balaji , Kaliappan Vishnu Kumar , Yahya Abid , Samikannu Ravi , Badruddin Irfan Anjum , Kamangar Sarfaraz , Hussien Mohamed TITLE=Decalcify cardiac CT: unveiling clearer images with deep convolutional neural networks JOURNAL=Frontiers in Medicine VOLUME=Volume 12 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1475362 DOI=10.3389/fmed.2025.1475362 ISSN=2296-858X ABSTRACT=Decalcification is crucial in enhancing the diagnostic accuracy and interpretability of cardiac CT images, particularly in cardiovascular imaging. Calcification in the coronary arteries and cardiac structures can significantly impact the quality of the images and hinder precise diagnostics. This study introduces a novel approach, Hybrid Models for Decalcify Cardiac CT (HMDC), aimed at enhancing the clarity of cardiac CT images through effective decalcification. Decalcification is critical in medical imaging, especially in cardiac CT scans, where calcification can hinder accurate diagnostics. The proposed HMDC leverages advanced deep-learning techniques and traditional image-processing methods for efficient and robust decalcification. The experimental results demonstrate the superior performance of HMDC, achieving an outstanding accuracy of 97.22%, surpassing existing decalcification methods. The hybrid nature of the model harnesses the strengths of both deep learning and traditional approaches, leading to more transparent and more diagnostically valuable cardiac CT images. The study underscores the potential impact of HMDC in improving the precision and reliability of cardiac CT diagnostics, contributing to advancements in cardiovascular healthcare. This research introduces a cutting-edge solution for decalcifying cardiac CT images and sets the stage for further exploration and refinement of hybrid models in medical imaging applications. The implications of HMDC extend beyond decalcification, opening avenues for innovation and improvement in cardiac imaging modalities, ultimately benefiting patient care and diagnostic accuracy.