AUTHOR=Guo Feiying , Zhong Huajie , Wu Yuan , Xu Xue , Tan Jiarong , Zhou Qiang , Tang Shunli 

TITLE=Dupilumab for treatment of primary cutaneous amyloidosis in adults: two case reports and literature review

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1485079

DOI=10.3389/fmed.2025.1485079

ISSN=2296-858X

ABSTRACT=Lichenoid amyloidosis (LA), a subtype of primary cutaneous amyloidosis (PCA), is featured by intensely pruritic, hyperkeratotic papules which lacks standardized treatment. Dupilumab, a human monoclonal antibody targeting for interleukin (IL)-4/13 receptor α chain, is widely applied in type 2 inflammation diseases treatment. This article reported two cases of refractory LA successfully treated with dupilumab and reviewed publications reporting dupilumab treatment for PCA.