AUTHOR=Kemala Sari Nina , Stepvia Stepvia , Ilyas Muhana Fawwazy , Setiati Siti , Harimurti Kuntjoro , Fitriana Ika 

TITLE=Handgrip strength as a potential indicator of aging: insights from its association with aging-related laboratory parameters

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1491584

DOI=10.3389/fmed.2025.1491584

ISSN=2296-858X

ABSTRACT=IntroductionThe aging process is frequently associated with a decline in functional capacity, endurance, muscle quality, and overall quality of life. Examining aging-related biomarkers often requires significant time and financial resources, underscoring the need for a straightforward and practical indicator. This study aims to investigate the association between handgrip strength and aging-related laboratory parameters in the elderly population of Indonesia.MethodsA cross-sectional study was conducted involving 109 participants aged 60–82 years. Handgrip strength was measured using a Jamar hydraulic hand dynamometer and Jamar PLUS+ digital dynamometer. Aging-related laboratory biomarkers were defined as those indicating physiological aging processes.ResultsThe study revealed a significant association between handgrip strength and several aging-related laboratory parameters, including leukocyte count, absolute neutrophil count, absolute lymphocyte count, neutrophil/lymphocyte ratio, and erythrocyte sedimentation rate.DiscussionThese findings suggest that handgrip strength could serve as a cost-effective, non-invasive predictor of aging-related health status in older adults. Its practical utility highlights its potential for guiding health interventions targeting the elderly population.