AUTHOR=Caggiano Valeria , Vitale Antonio , Hinojosa-Azaola Andrea , Guaracha-Basañez Guillermo Arturo , Ruscitti Piero , Cipriani Paola , Tharwat Samar , Elberashi Hanan M. , Othman Esraa E. , Conforti Alessandro , Gimignani Giancarlo , Erten Sukran , Barone Patrizia , Thabet Maissa , Sota Jurgen , Hernández-Rodríguez José , Gómez-Caverzaschi Verónica , Ragab Gaafar , Maher Amina , Batu Ezgi Deniz , Kawakami-Campos Perla Ayumi , Torres-Ruiz Jiram , Gaggiano Carla , Tufan Abdurrahman , Kucuk Hamit , Mayrink Giardini Henrique A. , Ahmed Guiga , Eksin Mehmet Akif , Fotis Lampros , Panahi Azadeh Shariat , Gentileschi Stefano , Almaghlouth Ibrahim A. , Sfikakis Petros P. , Fragoulis George E. , Monterosso Costanza , Opris-Belinski Daniela , Hashad Soad , Di Meglio Nunzia , Sica Cristian , Ulusoy Bahar Özdemir , de-la-Torre Alejandra , Wiesik-Szewczyk Ewa , Rybak Katarzyna , Balistreri Alberto , Fabiani Claudia , Mazzei Maria Antonietta , Frediani Bruno , Cantarini Luca TITLE=Development and implementation of the international AIDA network spondylarthritis registry JOURNAL=Frontiers in Medicine VOLUME=Volume 12 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1509357 DOI=10.3389/fmed.2025.1509357 ISSN=2296-858X ABSTRACT=During the last decade, spondyloarthritis (SpA) has increasingly been considered a disease at the crossroads between autoimmunity and autoinflammation. Some patients may even present with autoinflammatory-related manifestations, including fever, hidradenitis suppurativa, other neutrophilic dermatoses, and an unusually high increase in inflammatory markers. Therefore, a subgroup of SpA patients may be identified, and specific details about this cluster need to be investigated. In this regard, the AutoInflammatory Disease Alliance (AIDA) Network has developed a registry primarily aimed at better understanding the autoinflammatory aspects of SpA. The development of this Registry favors the systematic assessment of SpA through the lens of autoinflammation, giving a voice to patients with atypical presentations, and favoring a personalized treatment approach. By supporting research and facilitating the transfer of new evidence to clinical practice, this specific registry has the potential to significantly advance the field of rheumatology and enhance the lives of patients suffering from this complex and multifaceted disease.