AUTHOR=Zhu Ling-Na , Shen Wen-Bin , Zou Xiao-Yan , Zuo Jiang-Cheng , Xiao Ning 

TITLE=Chronic osteomyelitis with pathological fracture induced by Mycoplasma hominis infection: a case report and review of the literature

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1510753

DOI=10.3389/fmed.2025.1510753

ISSN=2296-858X

ABSTRACT=Mycoplasma hominis, commonly residing in the genitourinary tract, can cause rare extragenital infections, especially in immunocompromised individuals. This report details a case of chronic osteomyelitis with a pathological femur fracture in a 79-year-old woman. Despite a history of bone tuberculosis, the infection was identified as Mycoplasma hominis through culture and mass spectrometry, highlighting the diagnostic challenges due to the organism’s lack of a cell wall. This case underscores the necessity for advanced diagnostic methods and awareness of Mycoplasma hominis in non-urogenital infections.