AUTHOR=Dhariwal Rupal , Jain Mukul , Mir Yaser Rafiq , Singh Abhayveer , Jain Bhavik , Kumar Pankaj , Tariq Mohd , Verma Devvret , Deshmukh Khemraj , Yadav Virendra Kumar , Malik Tabarak 

TITLE=Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1522223

DOI=10.3389/fmed.2025.1522223

ISSN=2296-858X

ABSTRACT=Neurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. This study explores the potential of nanotherapeutics as a promising approach to enhance drug delivery across physiological barriers, particularly the blood–brain barrier (BBB) and blood-cerebrospinal fluid barrier (B-CSFB). By employing nanoparticles, this research aims to address critical challenges in the diagnosis and treatment of conditions such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. The multifactorial nature of these disorders necessitates innovative solutions that leverage nanomedicine to improve drug solubility, circulation time, and targeted delivery while minimizing off-target effects. The findings underscore the importance of advancing nanomedicine applications to develop effective therapeutic strategies that can alleviate the burden of neurodegenerative diseases on individuals and healthcare systems.