AUTHOR=Wang Pusen , Zhong Lin , Zhao Dong TITLE=Case report: Complete cast formation of the entire intrahepatic biliary tree JOURNAL=Frontiers in Medicine VOLUME=Volume 12 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1525442 DOI=10.3389/fmed.2025.1525442 ISSN=2296-858X ABSTRACT=Biliary complications pose substantial challenges in liver transplantation (LT), particularly with regard to non-anastomotic strictures (NASs). Among these ischemic-type biliary complications, bile cast syndrome (BCS) is a particularly severe condition. Currently, there are limited data on the formation of complete hepatic casts in BCS. In this case report, we present a unique instance of a second LT involving the formation of a complete hepatic bile cast and discuss its diagnostic and therapeutic process. This case aims to enhance the understanding of the anatomical and pathological features of BCS.