AUTHOR=Guarino Matteo , Perna Benedetta , Maroncelli Giacomo , Baldin Paolo , Donati Chiara , Luppi Francesco , Cesaro Alice Eleonora , Pesci Chiara , Costanzini Anna , Maritati Martina , Clavenzani Paolo , Contini Carlo , De Giorgio Roberto , Spampinato Michele Domenico 

TITLE=Variations in capillary and serum lactates levels based on different etiologies of septic patients in the emergency department

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1536148

DOI=10.3389/fmed.2025.1536148

ISSN=2296-858X

ABSTRACT=IntroductionSepsis is a life-threating and time-depending condition. This study examined the association between sepsis etiology and variations in capillary and serum lactate levels, neutrophil-to-lymphocyte ratio, and diastolic shock index in emergency department patients.MethodsThis study, conducted between 2021 and 2022 at the Emergency Department of Ferrara, included the following criteria: (i) clinical suspect of infectious disease; (ii) qSOFA ≥2; (iii) age ≥18 years; (iv) signed informed consent. Etiologies were: (i) negative cultures (NC); (ii) Gram positive (GP); (iii) Gram negative (GN); (iv) fungal infections (FI).ResultsAmong the 200 included patients, 104 (52.0%) had NC, 36 (18.0%) GP, 53 (26.5%) GN and 7 (3.5%) FI. CLs (p = 0.006) and SLs (p < 0.001) were different according to etiology being higher in GP infections. NLR (p = 0.035) was higher in GN infections, while DSI (p = 0.008) increased in FI. Mortality was not influenced by the etiology.ConclusionAll parameters differed according to sepsis etiology, thus improving early prediction of sepsis etiology and its pharmacological management.