AUTHOR=Si Yang , Cai Hongjiao , Hambly Brett D. , Wang Yuli , Zhang Yanfang , Bao Shisan (Bob) 

TITLE=Case Report: Endoscopic examination improves the diagnosis of inconspicuous helminth infections in adults in Shanghai

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1541099

DOI=10.3389/fmed.2025.1541099

ISSN=2296-858X

ABSTRACT=With advancements in medical care and improved public health in China, the incidence of hookworm infections has significantly decreased, particularly in first-tier cities. We report a case of severe microcytic hypochromic anaemia caused by hookworm disease. The patient received multiple blood transfusions for unexplained anaemia, with negative faecal smear results. GI endoscopic examination revealed hookworms in the pyloric ring, antrum, and duodenum, which were removed using biopsy forceps. Morphological analysis identified the worms as Ancylostoma duodenale. The patient was treated with a single dose of 400 mg albendazole and hematinics. Follow-up haemoglobin testing 3 months later showed an improvement to 126 g/L (115–150 g/L). This case highlights the importance of GI endoscopy diagnostics in identifying a typical presentations of hookworm disease, particularly in first-tier cities. Timely and accurate diagnosis of hookworm infections is essential for preventing long-term health consequences and reducing associated healthcare costs.