AUTHOR=Sherchan Amir , Jin Feng , Sherchan Bhakti , Mandal Sujit Kumar , Upadhaya Regmi Binit , Ghising Ranita , Upadhaya Sandesh Raj , Gautam Bishnu , Pathak Dipendra , Li Maoquan 

TITLE=Clinical significance of risk factor analysis in pancreatic cancer by using supervised model of machine learning

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1551926

DOI=10.3389/fmed.2025.1551926

ISSN=2296-858X

ABSTRACT=IntroductionPancreatic cancer (PC) poses a significant global health challenge due to its aggressive nature, late-stage diagnosis, and high mortality despite advancements in treatment. Early detection remains crucial for timely intervention. This study aimed to identify clinically relevant predictors of pancreatic cancer using a supervised machine learning approach and to develop a risk stratification tool with diagnostic capabilities.MethodsA matched case-control study was conducted retrospectively at the Tenth People’s Hospital of Tongji University (2017–2023), involving 353 cases and 370 matched controls. Demographic and hematological data were extracted from medical records. Variables were pre-selected using cluster dendrograms and subsequently refined using logistic regression with backward elimination and Support Vector Machine (SVM) models. A final risk scoring model was developed based on the best-performing model and internally validated.ResultsKey predictors retained in the final logistic regression model included Hemoglobin A1c (HbA1c) (OR 1.28; 95% CI: 1.08–1.52), Alkaline Phosphatase (ALP) (OR 1.02; 95% CI: 1.01–1.03), CA19-9 (OR 1.01; 95% CI: 1.01–1.01), Carcinoembryonic Antigen (CEA) (OR 1.41; 95% CI: 1.20–1.66), and Body Mass Index (BMI) (OR 0.88; 95% CI: 0.81–0.97). The final model demonstrated excellent diagnostic performance (AUC = 0.969, p < 0.001), with high accuracy, sensitivity, and specificity. A nomogram was constructed to facilitate individualized PC risk assessment.ConclusionHbA1c, ALP, CA19-9, CEA, and BMI were independently associated with pancreatic cancer. The machine learning-derived risk scoring model demonstrated high predictive accuracy and may serve as a valuable clinical tool for early detection and screening of pancreatic cancer.