AUTHOR=Li Jie , Pan Xinyan , Bi Yanting , Huang Jian , Peng Jun , Bai ChunLing , Hou Jianhong , Chen Yang 

TITLE=Comprehensive multi-omics analysis of tandem duplicator phenotypes in non-small cell lung cancer

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1556840

DOI=10.3389/fmed.2025.1556840

ISSN=2296-858X

ABSTRACT=IntroductionThe Tandem Duplicator Phenotype (TDP) is a prominent genomic metric prevalent in non-small cell lung cancer (NSCLC).MethodsMulti-omics samples including DNA copy number, transcriptomics, somatic single-nucleotide variations, clinical data, and cell-line drug sensitivity from TCGA and CCLE are delved into TDP characteristics.ResultsOur thorough analysis reveals that patients with smaller span sizes TDP have a more intricate genome, moderate pathology, enhanced therapeutic response, favorable prognosis, a more active immune system, and higher drug sensitivity. In contrast, those with larger span sizes TDP exhibited opposite trends.DiscussionThe integrated analysis underscores that an in-depth molecular assessment of TDP can offer invaluable insights into its role in cancers. Classification strategy of TDP could recognize the chemotherapy sensitivity of different NSCLC patients.