AUTHOR=Zhou You , Cheng Zhi , Gu Pingping , Zhang Yu , Xu Wanying , Wang Xin 

TITLE=Indicators of insulin resistance as predictors of 28-day mortality in patients with VA-ECMO: a retrospective study

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1559780

DOI=10.3389/fmed.2025.1559780

ISSN=2296-858X

ABSTRACT=BackgroundInsulin resistance is closely related to adverse outcomes in critical illness, but its predictive value in patients with cardiogenic shock receiving venous-arterial extracorporeal membrane oxygenation (VA-ECMO) remains unclear.MethodsPatients with cardiogenic shock who received VA-ECMO treatment were retrospectively included. To evaluate the associations of insulin resistance indicators such as triglyceride-glucose (TyG), metabolic score for insulin resistance (METS-IR), triglyceride-to-high-density-lipoprotein cholesterol ratio (TG/HDL-C), and triglyceride glucose-body mass index (TyG-BMI) with 28-day mortality. A multi-stage modeling strategy was adopted. Firstly, risk factors were screened through univariate and multivariate Cox regression; Further combine Least Absolute Shrinkage and Selection Operator (LASSO) regression (L1 regularization), random forest and gradient boosting machine (GBM) for multi-method feature screening, and use ridge regression (L2 regularization) to control collinearity to construct a joint prediction model; Finally, the model efficacy was verified through C-index, time-dependent receiver operating characteristic (ROC) curve, calibration curve, decision curve analysis (DCA), net reclassification improvement index (NRI), and comprehensive discriminant improvement index (IDI).ResultsTyG, METS-IR, TG/HDL-C, and TyG-BMI independently predicted an increased risk of death (all p < 0.01). Five core predictors were determined through multi-method screening: Sequential Organ Failure Assessment (SOFA) score, TyG, TG/HDL-C, hypertension, and diabetes. The joint model performed excellently in both the training set and the validation set (Training set: area under curve (AUC) = 0.923, C index = 0.847, NRI = 0.699, IDI = 0.175); Validation set: AUC = 0.901, C index = 0.846, NRI = 0.574, IDI = 0.148), and the DCA and calibration curve show its good efficacy.ConclusionInsulin resistance indicators (TyG, TG/HDL-C) can independently and gradually predict the risk of death in patients with VA-ECMO. The model combined with indicators such as SOFA score has high discriminative power and clinical practicability. This provides new evidence for risk stratification based on the integration of metabolism and organ function, supporting the research exploration of targeted intervention for insulin resistance to improve prognosis.