AUTHOR=Zhang Zijing , Liu Chuanbo , Li Jinsheng 

TITLE=Case Report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1565977

DOI=10.3389/fmed.2025.1565977

ISSN=2296-858X

ABSTRACT=Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by chronic infection with human papillomavirus (HPV), leading to disseminated flat-topped papules and pityriasis versicolor-like lesions. Patients with EV are predisposed to developing non-melanoma skin cancers, particularly squamous cell carcinoma (SCC) in sun-exposed areas. Currently, there is no definitive cure for EV, and management remains largely supportive and symptomatic. We report a case of EV in a 38-year-old male, presenting with classical clinical features and histopathological findings, complicated by the simultaneous development of squamous cell carcinoma(SCC) and basal cell carcinoma (BCC). This case highlights the oncogenic potential of EV-associated HPV subtypes and the importance of regular dermatologic surveillance in affected individuals.