AUTHOR=Li Mengmeng , Huang Chaoyuan , Xing Hailun , Luo Shijuan , Lin Yiqun , Kuang Yuxiang , Wang Jing , Huang Suiping , Ye Zhenhao 

TITLE=Epigastric pain of unknown origin, esophageal and gastric involvement: a Henoch-Schönlein Purpura case report

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1577291

DOI=10.3389/fmed.2025.1577291

ISSN=2296-858X

ABSTRACT=Henoch-Schönlein Purpura (HSP) is an acute systemic vasculitis that primarily affects the skin, gastrointestinal tract, kidneys and joints. It predominantly occurs in children but can occur at any age. We report a case of 48-year-old male patient suffering from unexplained epigastric pain alternating between relapses and remissions. The patient’s initial clinical manifestation was atypical, starting with severe epigastric pain, without cutaneous purpura, and with normal rheumatologic and immunologic markers, making diagnosis difficult. The patient was eventually diagnosed with HSP. This case highlights the importance of considering this diagnosis in patients with unexplained abdominal pain and emphasize the role of endoscopy in diagnosing complex cases.